Selectivity of ertapenem for Pseudomonas aeruginosa mutants cross-resistant to other carbapenems | Zendy

David M. Livermore | Zendy; Shazad Mushtaq | Zendy; Marina Warner | Zendy

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Selectivity of ertapenem for Pseudomonas aeruginosa mutants cross-resistant to other carbapenems

Author(s) -

David M. Livermore,

Shazad Mushtaq,

Marina Warner

Publication year - 2005

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dki009

Subject(s) - ertapenem , carbenicillin , imipenem , pseudomonas aeruginosa , microbiology and biotechnology , efflux , meropenem , carbapenem , mutant , biology , chemistry , antibiotics , bacteria , antibiotic resistance , biochemistry , ampicillin , gene , genetics

Ertapenem and other carbapenems will be used increasingly, as extended-spectrum beta-lactamases become more prevalent even among community-acquired pathogens. There is, however, concern that this use will select for resistances to imipenem and meropenem in nosocomial pathogens, notably Pseudomonas aeruginosa, and we investigated the validity of this concern.

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