A specific peptide inhibitor of the class B metallo-β-lactamase L-1 from Stenotrophomonas maltophilia identified using phage display | Zendy

François Sanschagrin | Zendy; Roger C. Lévesque | Zendy

Open Access

A specific peptide inhibitor of the class B metallo-β-lactamase L-1 from Stenotrophomonas maltophilia identified using phage display

Author(s) -

François Sanschagrin,

Roger C. Lévesque

Publication year - 2005

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkh550

Subject(s) - uncompetitive inhibitor , peptide , stenotrophomonas maltophilia , biopanning , phage display , biochemistry , non competitive inhibition , peptide library , active site , chemistry , peptide sequence , cyclic peptide , enzyme , biology , bacteria , pseudomonas aeruginosa , gene , genetics

In Gram-negative bacteria, resistance to beta-lactam antibiotics and to known inhibitors mediated by metallo-beta-lactamases is a major concern and a serious threat to public health. Since no clinically useful inhibitors are available against class B metallo-beta-lactamases, the aim of the study was to identify peptides as inhibitors.

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