Distribution of metronidazole in muscle tissue of patients with septic shock and its efficacy against Bacteroides fragilis in vitro | Zendy

Juri Karjagin | Zendy; Rein Pähkla | Zendy; Tõnis Karki | Zendy; Joel Starkopf | Zendy

Open Access

Distribution of metronidazole in muscle tissue of patients with septic shock and its efficacy against Bacteroides fragilis in vitro

Author(s) -

Juri Karjagin,

Rein Pähkla,

Tõnis Karki,

Joel Starkopf

Publication year - 2005

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkh544

Subject(s) - metronidazole , bacteroides fragilis , microdialysis , pharmacokinetics , pharmacodynamics , antibiotics , septic shock , in vitro , pharmacology , medicine , microbiology and biotechnology , chemistry , sepsis , biology , biochemistry , central nervous system

Studies investigating the target site concentration of antibiotics, such as beta-lactams and fluoroquinolones, have demonstrated differences between the drug concentrations in healthy volunteers and septic patients. The aims of this study were (i) to evaluate the muscle tissue concentration of metronidazole in patients with septic shock and (ii) to test the efficacy of metronidazole in an in vitro pharmacodynamic model at different single doses.

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