Regulated overexpression of CDR1 in Candida albicans confers multidrug resistance | Zendy

Masakazu Niimi | Zendy; Kyoko Niimi | Zendy; Yukie Takano | Zendy; Ann R. Holmes | Zendy; Frank Fischer | Zendy; Yoshimasa Uehara | Zendy; Richard D. Can | Zendy

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Regulated overexpression of CDR1 in Candida albicans confers multidrug resistance

Author(s) -

Masakazu Niimi,

Kyoko Niimi,

Yukie Takano,

Ann R. Holmes,

Frank Fischer,

Yoshimasa Uehara,

Richard D. Can

Publication year - 2004

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkh456

Subject(s) - candida albicans , efflux , corpus albicans , biology , microbiology and biotechnology , atp binding cassette transporter , heterologous expression , biochemistry , transporter , gene , recombinant dna

Information on the function of Candida albicans ATP-binding cassette (ABC) membrane transporter Cdr1p has come from studying the effect of gene inactivation in C. albicans and from heterologous Cdr1p expression in the yeast Saccharomyces cerevisiae. These approaches, however, give only an indirect indication of Cdr1p function in C. albicans itself. The objective of this study was to determine Cdr1p function in C. albicans by induced overexpression of Cdr1p in a C. albicans CDR1-deleted strain.

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