Therapeutic activity of a killer peptide against experimental paracoccidioidomycosis | Zendy

Luiz R. Travassos | Zendy; Luis S. Silva | Zendy; Elaine G. Rodrigues | Zendy; Stefania Conti | Zendy; Antonella Salati | Zendy; Walter Magliani | Zendy; Luciano Polonelli | Zendy

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Therapeutic activity of a killer peptide against experimental paracoccidioidomycosis

Author(s) -

Luiz R. Travassos,

Luis S. Silva,

Elaine G. Rodrigues,

Stefania Conti,

Antonella Salati,

Walter Magliani,

Luciano Polonelli

Publication year - 2004

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkh430

Subject(s) - paracoccidioides brasiliensis , paracoccidioidomycosis , in vivo , in vitro , biology , microbiology and biotechnology , spleen , paracoccidioides , yeast , pharmacology , immunology , biochemistry

To evaluate whether an engineered synthetic decapeptide (KP) derived from the sequence of a recombinant anti-idiotypic antibody, that represents the internal image of a Pichia anomala killer toxin, could be fungicidal in vitro and therapeutic in vivo against Paracoccidioides brasiliensis and paracoccidioidomycosis (PCM).

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