Reversion to susceptibility in a linezolid-resistant clinical isolate of Staphylococcus aureus | Zendy

Venkata G. Meka | Zendy; Howard S. Gold | Zendy; Amy C. Cooke | Zendy; Lata Venkataraman | Zendy; George M. Eliopoulos | Zendy; Robert C. Moellering | Zendy; Stephen G. Jenkins | Zendy

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Reversion to susceptibility in a linezolid-resistant clinical isolate of Staphylococcus aureus

Author(s) -

Venkata G. Meka,

Howard S. Gold,

Amy C. Cooke,

Lata Venkataraman,

George M. Eliopoulos,

Robert C. Moellering,

Stephen G. Jenkins

Publication year - 2004

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkh423

Subject(s) - 23s ribosomal rna , linezolid , staphylococcus aureus , microbiology and biotechnology , biology , ribosomal rna , mutant , gene , reversion , mutation , genetics , bacteria , rna , vancomycin , phenotype , ribosome

Linezolid resistance in rare isolates of Staphylococcus aureus has been associated with G2576T mutations in domain V of the 23S rRNA gene. We report the analysis of a clinical S. aureus isolate that developed linezolid resistance (MIC of linezolid of 12 mg/L) after a 25 day course of the drug. Sequencing identified G2576T mutations in four of the five copies of the 23S rRNA gene.

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