Pseudomonas aeruginosa-induced infection and degradation of human wound fluid and skin proteins ex vivo are eradicated by a synthetic cationic polymer | Zendy

Maria Werthén | Zendy; Mina Davoudi | Zendy; Andreas Sonesson | Zendy; D. Patric Nitsche | Zendy; Matthias Mörgelin | Zendy; Kristina Blom | Zendy; Artur Schmidtchen | Zendy

Open Access

Pseudomonas aeruginosa-induced infection and degradation of human wound fluid and skin proteins ex vivo are eradicated by a synthetic cationic polymer

Author(s) -

Maria Werthén,

Mina Davoudi,

Andreas Sonesson,

D. Patric Nitsche,

Matthias Mörgelin,

Kristina Blom,

Artur Schmidtchen

Publication year - 2004

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkh407

Subject(s) - pseudomonas aeruginosa , microbiology and biotechnology , cathelicidin , ex vivo , bacteria , human skin , antimicrobial , in vivo , innate immune system , antimicrobial peptides , elastase , wound healing , biology , immune system , chemistry , immunology , biochemistry , enzyme , genetics

Antimicrobial peptides are important effectors of innate immunity. Bacteria display multiple defence mechanisms against these peptides. For example, Pseudomonas aeruginosa releases potent proteinases that inactivate the human cathelicidin LL-37. Hence, in conditions characterized by persistent bacterial colonization, such as in P. aeruginosa-infected skin wounds, there is a need for efficient means of reducing bacterial load. Here, the effect of the cationic molecule polyhexamethylenebiguanide (PHMB) was evaluated.

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