Release of calcium from intracellular stores and subsequent uptake by mitochondria are essential for the candidacidal activity of an N-terminal peptide of human lactoferrin | Zendy

Antonella Lupetti | Zendy; Carlo Brouwer | Zendy; Heleen E. C. Dogterom-Ballering | Zendy; Sonia Senesi | Zendy; Mario Campa | Zendy; Jaap T. van Dissel | Zendy; Peter H. Nibbering | Zendy

Open Access

Release of calcium from intracellular stores and subsequent uptake by mitochondria are essential for the candidacidal activity of an N-terminal peptide of human lactoferrin

Author(s) -

Antonella Lupetti,

Carlo Brouwer,

Heleen E. C. Dogterom-Ballering,

Sonia Senesi,

Mario Campa,

Jaap T. van Dissel,

Peter H. Nibbering

Publication year - 2004

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkh385

Subject(s) - lactoferrin , candida albicans , peptide , mitochondrion , intracellular , chemistry , biochemistry , microbiology and biotechnology , biology

Earlier studies showed that mitochondrial damage is a hallmark of the candidacidal activity of an N-terminal peptide of human lactoferrin, further referred to as hLF(1-11). Since uptake of Ca(2+) by mitochondria may be essential for their activation, the aim of this study was to define the role of Ca(2+) in killing of Candida albicans by the hLF(1-11) peptide.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research