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Type II topoisomerase mutations in Bacillus anthracis associated with high-level fluoroquinolone resistance
Author(s) -
Darrin J. Bast,
Abed Athamna,
Carla Duncan,
Joyce C. S. de Azavedo,
Donald E. Low,
Galia Rahav,
David J. Farrell,
Ethan Rubinstein
Publication year - 2004
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkh294
Subject(s) - efflux , bacillus anthracis , ofloxacin , microbiology and biotechnology , broth microdilution , topoisomerase iv , dna gyrase , biology , quinolone , levofloxacin , gene , bacteria , antibiotics , genetics , escherichia coli , ciprofloxacin , minimum inhibitory concentration
To identify and characterize the mechanisms of high-level fluoroquinolone resistance in two strains of Bacillus anthracis following serial passage in increasing concentrations of fluoroquinolones.

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