Perioperative pharmacokinetics of cefotaxime in serum and bile during continuous and intermittent infusion in liver transplant patients | Zendy

S.E. Buijk | Zendy

Open Access

Perioperative pharmacokinetics of cefotaxime in serum and bile during continuous and intermittent infusion in liver transplant patients

Author(s) -

S.E. Buijk

Publication year - 2004

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkh268

Subject(s) - pharmacokinetics , liver transplantation , medicine , pharmacodynamics , transplantation , perioperative , gastroenterology , volume of distribution , cefotaxime , bolus (digestion) , pharmacology , urology , area under the curve , anesthesia , chemistry , antibiotics , biochemistry

Drug pharmacokinetics may be altered during liver transplantation. Cefotaxime (CTX), used as perioperative prophylaxis, demonstrates time-dependent killing and therefore continuous infusion might have pharmacodynamic advantages.

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