Susceptibility of porcine cytomegalovirus to antiviral drugs | Zendy

Jacqueline F. Fryer | Zendy

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Susceptibility of porcine cytomegalovirus to antiviral drugs

Author(s) -

Jacqueline F. Fryer

Publication year - 2004

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkh231

Subject(s) - xenotransplantation , virology , cytomegalovirus , human cytomegalovirus , consumptive coagulopathy , antiviral drug , virus , immunology , medicine , biology , transplantation , herpesviridae , viral disease , platelet , surgery

Re-activation of porcine cytomegalovirus (PCMV) in the xenograft has been reported in pig-to-baboon models of xenotransplantation and is associated with invasive disease and consumptive coagulopathy. If xenotransplantation of porcine organs into human recipients is to proceed, donor organs will have to be free from a wide range of infectious agents including PCMV. However, it is prudent to characterize the antiviral susceptibility of this virus. We therefore investigated the effect of selected antiviral agents, currently licensed for the treatment of human herpesvirus infections, on PCMV replication.

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