Characterization of the molecular mechanisms of quinolone resistance in Yersinia enterocolitica O:3 clinical isolates | Zendy

Sílvia Capilla | Zendy

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Characterization of the molecular mechanisms of quinolone resistance in Yersinia enterocolitica O:3 clinical isolates

Author(s) -

Sílvia Capilla

Publication year - 2004

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkh225

Subject(s) - nalidixic acid , yersinia enterocolitica , microbiology and biotechnology , quinolone , efflux , biology , enterobacteriaceae , bacteria , dna gyrase , gene , antibiotics , antibiotic resistance , escherichia coli , genetics

The aim of this study was to determine the roles of mutations in the gyrA and parC genes and the overexpression of efflux pump(s) as mechanisms of resistance to quinolones. Forty-five Yersinia enterocolitica O:3 clinical isolates (41 nalidixic acid-resistant, three nalidixic acid-susceptible and one nalidixic acid-resistant strain obtained in vitro) were analysed.

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