Enhancement of host fitness by the sul2-coding plasmid p9123 in the absence of selective pressure | Zendy

Virve I. Enne | Zendy

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Enhancement of host fitness by the sul2-coding plasmid p9123 in the absence of selective pressure

Author(s) -

Virve I. Enne

Publication year - 2004

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkh217

Subject(s) - plasmid , escherichia coli , biology , linkage (software) , drug resistance , host (biology) , microbiology and biotechnology , genetics , gene

Despite a 97% reduction in clinical sulphonamide usage, the prevalence of sulphonamide resistance among Escherichia coli has remained constant in the UK. Genetic linkage of sulphonamide resistance to other resistances is thought important for this maintenance, but the finding also implies that sulphonamide resistance exerts little fitness cost. To test this hypothesis, we examined the fitness impact of four naturally occurring sul2-coding plasmids upon their hosts.

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