Mode of action of an antimicrobial biomaterial for use in hydrocephalus shunts | Zendy

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Mode of action of an antimicrobial biomaterial for use in hydrocephalus shunts

Author(s) -

Roger Bayston

Publication year - 2004

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkh183

Subject(s) - antimicrobial , staphylococcus epidermidis , antibiotics , hydrocephalus , bacteria , shunt (medical) , microbiology and biotechnology , biofilm , medicine , staphylococcus aureus , staphylococcus , surgery , biology , genetics

Infection remains a major complication of shunting for hydrocephalus. The causative bacteria, mainly staphylococci, gain access to the shunt at operation and colonize the shunt tubing. This leads to biofilm development requiring shunt removal. As there is no clear evidence to support antibiotic prophylaxis, we have developed an impregnated antimicrobial shunt material. This study aimed to elucidate its mode of action in terms of bacterial adherence and killing kinetics.

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