Diffusion of levofloxacin into bone and synovial tissues | Zendy

Thomas Rimmelé | Zendy

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Diffusion of levofloxacin into bone and synovial tissues

Author(s) -

Thomas Rimmelé

Publication year - 2004

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkh110

Subject(s) - levofloxacin , cancellous bone , bone tissue , medicine , chemistry , synovial fluid , pathology , antibiotics , osteoarthritis , biochemistry , alternative medicine

The degree of penetration of an antibiotic into the infected site is an important determinant of therapeutic success. Levofloxacin is widely used in the treatment of serious infections. However, there are only few studies concerning its diffusion into bone tissue and none concerning its diffusion into synovial tissue. Our objective was to quantify levofloxacin bone and synovial tissue penetration and to compare our data with the breakpoint for susceptible organisms.

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