Open AccessOral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor
Author(s) -
Matthew Gross
Publication year - 2004
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkh108
Subject(s) - pharmacokinetics , pharmacology , streptococcus pneumoniae , peritonitis , in vivo , bioavailability , cmax , volume of distribution , oral administration , biology , microbiology and biotechnology , medicine , antibiotics
BB-81384, a novel peptide deformylase (PDF) inhibitor, was characterized in terms of enzyme inhibition profile, antibacterial activity, rodent pharmacokinetics and oral efficacy in murine infection models.
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