In vitro activity and mode of action of diastereomeric antimicrobial peptides against bacterial clinical isolates | Zendy

Ulrike Pag | Zendy

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In vitro activity and mode of action of diastereomeric antimicrobial peptides against bacterial clinical isolates

Author(s) -

Ulrike Pag

Publication year - 2004

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkh083

Subject(s) - antimicrobial , diastereomer , mode of action , antibiotics , antimicrobial peptides , microbiology and biotechnology , bacteria , antibacterial activity , biology , population , in vitro , peptide , antibacterial agent , potency , minimum inhibitory concentration , chemistry , biochemistry , stereochemistry , medicine , genetics , environmental health

Increasing resistance of pathogenic bacteria to antibiotics is a severe problem in health care and has intensified the search for novel drugs. Cationic antibacterial peptides are the most abundant antibiotics in nature and have been frequently proposed as new anti-infective agents. Here, a group of diastereomeric (containing d- and l-amino acids) peptides is studied regarding their potency against multiply resistant clinical isolates and their modes of action against Gram-positive cocci.

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