Overexpression of the multidrug efflux pump SmeDEF impairs Stenotrophomonas maltophilia physiology | Zendy

Andrés M. Alonso | Zendy

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Overexpression of the multidrug efflux pump SmeDEF impairs Stenotrophomonas maltophilia physiology

Author(s) -

Andrés M. Alonso

Publication year - 2004

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkh074

Subject(s) - stenotrophomonas maltophilia , efflux , antibiotics , microbiology and biotechnology , antibiotic resistance , multiple drug resistance , biology , stenotrophomonas , drug resistance , bacteria , pseudomonas aeruginosa , genetics , pseudomonas

The use of antibiotics for the treatment of infectious diseases has led to important changes in the structure of pathogenic bacterial populations. However, these changes could be buffered if the expression of antibiotic resistance genes were to lead to the counter-selection of antibiotic-resistant strains in antibiotic-free environments. To test the effect of antibiotic resistance on bacterial fitness, we analysed the effect of the overproduction of the multidrug efflux pump SmeDEF on the physiology of Stenotrophomonas maltophilia. SmeDEF confers resistance to antibiotics belonging to different structural families, and its overexpression is associated with an antibiotic resistance phenotype in clinical isolates of S. maltophilia.

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