Accumulation of garenoxacin by Bacteroides fragilis compared with that of five fluoroquinolones | Zendy

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Accumulation of garenoxacin by Bacteroides fragilis compared with that of five fluoroquinolones

Author(s) -

Vito Ricci

Publication year - 2003

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkg418

Subject(s) - bacteroides fragilis , microbiology and biotechnology , bacteroidaceae , bacteroides , cephalosporin , antibacterial agent , antibiotics , chemistry , biology , bacteria , genetics

Garenoxacin is a novel des-F(6)-quinolone with good anti-anaerobe activity. The accumulation of garenoxacin and five other quinolones in the presence and absence of a variety of efflux pump inhibitors, including carbonyl cyanide m-chlorophenyl hydrazone (CCCP: 100 microM), verapamil (25 microM), reserpine (20 mg/L), sodium orthovanadate (50 microM) and Phe-Arg-beta-naphthylamide (MC-207110) (20 mg/L) was investigated.

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