Efficacy of caspofungin combined with amphotericin B against azole-resistant Candida albicans | Zendy

Mozammal Hossain | Zendy

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Efficacy of caspofungin combined with amphotericin B against azole-resistant Candida albicans

Author(s) -

Mozammal Hossain

Publication year - 2003

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkg230

Subject(s) - caspofungin , azole , amphotericin b , candida albicans , in vivo , microbiology and biotechnology , in vitro , pharmacology , biology , corpus albicans , antifungal , biochemistry

The activity of caspofungin (CFG) combined with amphotericin B (AMB) against azole-resistant Candida albicans was evaluated in vitro (chequerboard) and in vivo (murine). CFG+AMB resulted in positive interactive effects in vitro (fractional inhibitory concentration index 0.75). Compared with untreated controls, CFG+AMB prolonged mouse survival (P = 0.006) and compared with AMB alone, CFG+AMB prolonged mouse survival (P = 0.36); however, the latter difference was not significant. CFG+AMB treatment significantly reduced kidney cfu compared with untreated controls and CFG-treated groups (P < or = 0.05 for both comparisons). In addition, this combination reduced brain cfu significantly compared with untreated controls and AMB-treated mice (P = 0.005 and 0.05, respectively).

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