Aspects of the antimicrobial mechanisms of action of a polyquaternium and an amidoamine | Zendy

Caroline E. Codling | Zendy; JeanYves Maillard | Zendy; A.D. Russell | Zendy

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Aspects of the antimicrobial mechanisms of action of a polyquaternium and an amidoamine

Author(s) -

Caroline E. Codling,

JeanYves Maillard,

A.D. Russell

Publication year - 2003

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkg228

Subject(s) - microbiology and biotechnology , aspergillus fumigatus , serratia marcescens , candida albicans , spheroplast , lysis , antimicrobial , biology , corpus albicans , chemistry , biochemistry , escherichia coli , gene

Polyquad (Alcon) (polyquaternium-1, PQ-1) and Aldox (Alcon) (myristamidopropyl dimethylamine, MAPD) are two biocides that are used commercially in a contact lens disinfecting solution, namely Opti-Free Express (Alcon) multi-purpose disinfecting solution. Their potential mechanisms of action were investigated against a range of common ocular pathogens. These were Acanthamoeba castellanii (trophozoites and cysts), Aspergillus fumigatus, Candida albicans, Pseudomonas aeruginosa, Serratia marcescens and Staphylococcus aureus.

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