Effects of mupirocin at subinhibitory concentrations on flagella formation in Pseudomonas aeruginosa and Proteus mirabilis | Zendy

Toshinobu Horii | Zendy; Motoki Morita | Zendy; Hideaki Muramatsu | Zendy; Yoshinori Muranaka | Zendy; Takashi Kanno | Zendy; Masato Maekawa | Zendy

Open Access

Effects of mupirocin at subinhibitory concentrations on flagella formation in Pseudomonas aeruginosa and Proteus mirabilis

Author(s) -

Toshinobu Horii,

Motoki Morita,

Hideaki Muramatsu,

Yoshinori Muranaka,

Takashi Kanno,

Masato Maekawa

Publication year - 2003

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkg226

Subject(s) - proteus mirabilis , microbiology and biotechnology , pseudomonas aeruginosa , flagellin , flagellum , mupirocin , virulence , biology , swarming motility , bacteria , quorum sensing , staphylococcus aureus , gene , methicillin resistant staphylococcus aureus , genetics , biochemistry

Colonization of Pseudomonas aeruginosa at trachea, nares and oropharynx can cause ventilator-acquired pneumonia. To identify beneficial effects of antibiotics on expression of virulence factors related to colonization by such pathogens, we evaluated the effect of mupirocin on flagella formation in P. aeruginosa and on motility and flagella formation in Proteus mirabilis. In P. aeruginosa, subinhibitory concentrations of mupirocin inhibited flagella formation, which was associated with reduced flagellin expression. In P. mirabilis, subinhibitory concentrations of mupirocin dose-dependently suppressed bacterial motility and flagella formation, again with reduced flagellin expression. Our results indicate that subinhibitory concentrations of mupirocin can suppress expression of virulence factors in P. aeruginosa and P. mirabilis.

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