Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection | Zendy

Joaquı́m Ruiz | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection

Author(s) -

Joaquı́m Ruiz

Publication year - 2003

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkg222

Subject(s) - dna gyrase , efflux , quinolone , microbiology and biotechnology , bacteria , antibacterial agent , biology , antibiotics , antibiotic resistance , chemistry , gene , escherichia coli , genetics

Quinolones are broad-spectrum antibacterial agents, commonly used in both clinical and veterinary medicine. Their extensive use has resulted in bacteria rapidly developing resistance to these agents. Two mechanisms of quinolone resistance have been established to date: alterations in the targets of quinolones, and decreased accumulation due to impermeability of the membrane and/or an overexpression of efflux pump systems. Recently, mobile elements have also been described, carrying the qnr gene, which confers resistance to quinolones.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research