Induction of mexCD-oprJ operon for a multidrug efflux pump by disinfectants in wild-type Pseudomonas aeruginosa PAO1 | Zendy

Yuji Morita | Zendy; Takeshi Murata | Zendy; Takehiko Mima | Zendy; Sumiko Shiota | Zendy; Teruo Kuroda | Zendy; Tohru Mizushima | Zendy; Naomasa Gotoh | Zendy; Takeshi Nishino | Zendy; Tomofusa Tsuchiya | Zendy

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Induction of mexCD-oprJ operon for a multidrug efflux pump by disinfectants in wild-type Pseudomonas aeruginosa PAO1

Author(s) -

Yuji Morita,

Takeshi Murata,

Takehiko Mima,

Sumiko Shiota,

Teruo Kuroda,

Tohru Mizushima,

Naomasa Gotoh,

Takeshi Nishino,

Tomofusa Tsuchiya

Publication year - 2003

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkg173

Subject(s) - efflux , pseudomonas aeruginosa , microbiology and biotechnology , norfloxacin , ethidium bromide , multiple drug resistance , yersinia ruckeri , biology , operon , chemistry , ciprofloxacin , antibiotics , escherichia coli , bacteria , biochemistry , dna , genetics , fishery , fish <actinopterygii> , gene , rainbow trout

Induction of the MexCD-OprJ multidrug efflux pump was investigated in wild-type Pseudomonas aeruginosa PAO1. MexCD-OprJ was induced by clinically important disinfectants such as benzalkonium chloride and chlorhexidine gluconate, and by some cytotoxic agents such as tetraphenylphosphonium chloride, ethidium bromide and rhodamine 6G. MexCD-OprJ was not induced by norfloxacin, tetracycline, chloramphenicol, streptomycin, erythromycin or carbenicillin, although they are substrates for the pump. Cells of PAO1 showed increased resistance to norfloxacin when grown in the presence of the inducers of the mexCD-oprJ operon mentioned above. These results indicate that MexCD-OprJ plays an important role in intrinsic multidrug resistance in wild-type P. aeruginosa in hospitals where disinfectants are used frequently.

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