An integron cassette encoding erythromycin esterase, ere(A), from Providencia stuartii | Zendy

Ianik Plante | Zendy

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An integron cassette encoding erythromycin esterase, ere(A), from Providencia stuartii

Author(s) -

Ianik Plante

Publication year - 2003

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkg169

Subject(s) - integron , biology , providencia , plasmid , genetics , microbiology and biotechnology , erythromycin , gene , escherichia coli , enterobacteriaceae , antibiotics

We have mapped the variable region of the two class 1 integrons found in the multiresistant strain Providencia stuartii 1723. Integron 1 contains a new arrangement of gene cassettes, aacA4-aadB-aadA1, conferring resistance to all aminoglycosides used for clinical treatment. Integron 2 contains a variant of the gene cassette ere(A), coding for an erythromycin esterase, whose nucleotide sequence shares 93.7% DNA identity with ere(A) from Escherichia coli BM2195 plasmid pIP1100.

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