Open AccesssiRNAs: a new wave of RNA-based therapeutics
Author(s) -
Glen A. Coburn
Publication year - 2003
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkg166
Subject(s) - rna interference , gene silencing , small interfering rna , trans acting sirna , rna silencing , biology , gene expression , gene , microbiology and biotechnology , computational biology , rna , genetics
This non-specific response to dsRNAleads to global changes in cellular gene expression andapoptosis, masking any specific silencing effect by RNAi inmammalian cells. Recently, however, it was shown that potentand specific gene silencing could be achieved in human cellstransfected with small interfering RNAs (siRNA) of 21 –23 nt,a key intermediate in the RNAi pathway.
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