Bactericidal activity of daptomycin against Streptococcus pneumoniae compared with eight other antimicrobials | Zendy

Glenn A. Pankuch | Zendy

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Bactericidal activity of daptomycin against Streptococcus pneumoniae compared with eight other antimicrobials

Author(s) -

Glenn A. Pankuch

Publication year - 2003

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkg091

Subject(s) - daptomycin , teicoplanin , linezolid , dalfopristin , microbiology and biotechnology , quinupristin , lipopeptide , antibiotics , streptococcus pneumoniae , vancomycin , antimicrobial , antibacterial agent , minimum inhibitory concentration , medicine , biology , staphylococcus aureus , bacteria , genetics

A spectrum of pneumococci with varying susceptibilities to beta-lactams, macrolides and quinolones was tested for susceptibility to nine antibiotics, including the novel lipopeptide daptomycin. Daptomycin was active against all strains (MIC range </=0.5 mg/L; MIC(50) 0.125 mg/L; MIC(90) 0.25 mg/L). All pneumococci were susceptible to vancomycin, teicoplanin, linezolid and quinupristin/dalfopristin, with MICs < 4.0 mg/L. Time-kill assays with eight strains demonstrated that daptomycin (2 x MIC) was bactericidal in seven of eight strains tested at 24 h, with >90% killing at 1 h.

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