Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species | Zendy

Dimitrios P. Kontoyiannis | Zendy; Russell E. Lewis | Zendy; Nir Osherov | Zendy; Nathaniel D. Albert | Zendy; Gregory S. May | Zendy

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Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species

Author(s) -

Dimitrios P. Kontoyiannis,

Russell E. Lewis,

Nir Osherov,

Nathaniel D. Albert,

Gregory S. May

Publication year - 2003

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkg090

Subject(s) - caspofungin , calcineurin , biology , microbiology and biotechnology , in vitro , cryptococcus neoformans , aspergillus fumigatus , pharmacology , biochemistry , antifungal , voriconazole , medicine , transplantation

Work in Saccharomyces cerevisiae and Cryptococcus neoformans suggests that caspofungin could interact with the calcineurin pathway. We examined the in vitro interaction of caspofungin with calcineurin inhibitors (FK506, cyclosporin, FK520 and L685,818) and the TOR inhibitor rapamycin in 13 isolates of Aspergillus species. Caspofungin activity was enhanced by calcineurin/TOR inhibitors for all Aspergillus isolates studied. Further investigation of this pathway is warranted.

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