Open AccessIdentification of novel inhibitors of Pseudomonas aeruginosa MurC enzyme derived from phage-displayed peptide libraries
Author(s) -
Ahmed El Zoeiby
Publication year - 2003
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkg010
Subject(s) - biopanning , peptide , escherichia coli , biochemistry , peptide library , peptidoglycan , biology , enzyme , biosynthesis , phage display , peptide sequence , chemistry , microbiology and biotechnology , gene
The machinery of peptidoglycan biosynthesis is an ideal site at which to look for novel antimicrobial targets. Phage display was used to develop novel peptide inhibitors for MurC, an essential enzyme involved in the early steps of biosynthesis of peptidoglycan monomer.
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