Selective lethal photosensitization of methicillin-resistant Staphylococcus aureus using an IgG-tin (IV) chlorin e6 conjugate | Zendy

Michelle L. Embleton | Zendy; Sean P. Nair | Zendy; B. Cookson | Zendy; Michael Wilson | Zendy

Open Access

Selective lethal photosensitization of methicillin-resistant Staphylococcus aureus using an IgG-tin (IV) chlorin e6 conjugate

Author(s) -

Michelle L. Embleton,

Sean P. Nair,

B. Cookson,

Michael Wilson

Publication year - 2002

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkf209

Subject(s) - photosensitizer , conjugate , staphylococcus aureus , microbiology and biotechnology , chemistry , antimicrobial , photodynamic therapy , chlorin , methicillin resistant staphylococcus aureus , staphylococcal infections , biology , bacteria , photochemistry , mathematical analysis , mathematics , organic chemistry , genetics

The growing resistance of methicillin-resistant Staphylococcus aureus (MRSA) to conventional antimicrobial agents necessitates the development of alternative approaches to preventing and treating infections. One such approach is photodynamic therapy, whereby target cells are treated with light-activated drugs (photosensitizers). This investigation aimed to determine whether the ability of MRSA to express the IgG-binding protein, protein A, could be exploited to enable selective lethal photosensitization of the organism with a photosensitizer [tin (IV) chlorin e6; SnCe6] linked to IgG.

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