Pharmacokinetics and ocular penetration of grepafloxacin in albino and pigmented rabbits | Zendy

S. Pérez Oliván | Zendy

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Pharmacokinetics and ocular penetration of grepafloxacin in albino and pigmented rabbits

Author(s) -

S. Pérez Oliván

Publication year - 2002

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkf178

Subject(s) - pharmacokinetics , medicine , penetration (warfare) , pharmacology , animal model , antibiotics , anesthesia , biology , microbiology and biotechnology , operations research , engineering

The pharmacokinetics of grepafloxacin were determined in albino and pigmented rabbits following a single 10 mg/kg intravenous administration. The penetration of grepafloxacin into various ocular tissues was also determined after continuous intravenous infusion in both types of animal. Grepafloxacin showed a bicompartmental model of distribution in both pigmented and albino rabbits with significant differences in the pharmacokinetics between the two types of animal. After continuous intravenous infusion, significantly greater penetration of grepafloxacin was found in the iris, cornea and chorioretina of pigmented rabbits compared with albino rabbits.

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