A prospective study of the clarithromycin-digoxin interaction in elderly patients | Zendy

Pedro Zapater | Zendy

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A prospective study of the clarithromycin-digoxin interaction in elderly patients

Author(s) -

Pedro Zapater

Publication year - 2002

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkf176

Subject(s) - digoxin , clarithromycin , medicine , pharmacokinetics , observational study , drug interaction , elimination rate constant , prospective cohort study , pharmacology , heart failure , volume of distribution , helicobacter pylori

The study was a prospective observational trial carried out to assess the clarithromycin-digoxin interaction in elderly patients chronically taking digoxin. Digoxin concentrations were determined before and after concomitant treatment with clarithromycin. A Bayesian approach was used to calculate digoxin pharmacokinetics. In the seven patients who were studied there was a significant increase in digoxin concentration after 4-7 days of clarithromycin treatment; digoxin clearance and elimination rate constant were 56-60% lower and elimination half-life was 82% longer. The pharmacokinetic clarithromycin-digoxin interaction in the elderly may be much more frequent than has been assumed up to now.

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