Enhanced contact activity of fluconazole in association with antioxidants against fluconazole-resistant organisms | Zendy

Giovanna Simonetti | Zendy

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Enhanced contact activity of fluconazole in association with antioxidants against fluconazole-resistant organisms

Author(s) -

Giovanna Simonetti

Publication year - 2002

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkf102

Subject(s) - fluconazole , butylated hydroxyanisole , candida albicans , microbiology and biotechnology , chemistry , escherichia coli , membrane permeability , biology , antifungal , membrane , biochemistry , antioxidant , gene

Fluconazole alone does not demonstrate any contact activity against resistant organisms. Phenolic antioxidants, such as butylated hydroxyanisole, appear to promote fluconazole activity resulting in the killing of 10(4) cfu/mL of 11 resistant Candida albicans strains within 3-15 min and of 10(4) cfu/mL of 10 resistant Escherichia coli strains within 6-15 min. Fluconazole activity was increased by the addition of ethyl alcohol (20%). Antioxidants appear to promote fluconazole activity by increasing cell membrane permeability. This combination has potential advantages in the administration of topical fluconazole.

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