Susceptibility testing of Aspergillus spp. by means of an automated blood culture system | Zendy

P.M. Rath | Zendy

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Susceptibility testing of Aspergillus spp. by means of an automated blood culture system

Author(s) -

P.M. Rath

Publication year - 2002

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkf073

Subject(s) - amphotericin b , microbiology and biotechnology , broth microdilution , aspergillus , blood culture , biology , fungi imperfecti , incubation , incubation period , fungemia , inoculation , minimum inhibitory concentration , antibiotics , antifungal , immunology , biochemistry

The BacT/Alert blood culture system was evaluated for the MIC determination of amphotericin B for 27 strains of Aspergillus from five different species. An inoculum of c. 10(8) cfu/mL and an incubation time of 48 h resulted in MICs for 26 of 27 strains that corresponded with published MICs obtained in a microdilution assay. Twelve of 13 strains with MIC(48) values >/=2 mg/L showed growth within 24 h in bottles containing 0.25 mg/L amphotericin B, indicating that results can be obtained the day following inoculation. It is concluded that the BacT/Alert blood culture system can be used for susceptibility testing of Aspergillus spp. with amphotericin B.

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