Resistance to macrolides in clinical isolates of Streptococcus pyogenes due to ribosomal mutations | Zendy

Brigitte Malbruny | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Resistance to macrolides in clinical isolates of Streptococcus pyogenes due to ribosomal mutations

Author(s) -

Brigitte Malbruny

Publication year - 2002

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkf038

Subject(s) - streptococcus pyogenes , microbiology and biotechnology , erythromycin , biology , azithromycin , efflux , gene , 23s ribosomal rna , ribosomal rna , antibiotics , bacteria , genetics , ribosome , staphylococcus aureus , rna

Two clinical strains of Streptococcus pyogenes, 237 and 544, one isolated in Slovakia and the other in Croatia, that were resistant to azithromycin (MIC 8 and 2 mg/L, respectively) but susceptible to erythromycin (MIC 0.5 and 0.12 mg/L, respectively) did not contain any gene known to confer macrolide resistance by ribosomal modification (erm gene) or efflux [mef(A) and msr(A) genes]. The aim of the study was to determine the mechanisms of macrolide resistance in both strains.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research