Intracellular activity of ABT-773 and other antimicrobial agents against Legionella pneumophila | Zendy

Rose Jung | Zendy; Larry H. Danziger | Zendy; Susan L. Pendland | Zendy

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Intracellular activity of ABT-773 and other antimicrobial agents against Legionella pneumophila

Author(s) -

Rose Jung,

Larry H. Danziger,

Susan L. Pendland

Publication year - 2002

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkf017

Subject(s) - legionella pneumophila , azithromycin , ciprofloxacin , microbiology and biotechnology , minimum inhibitory concentration , antimicrobial , antibacterial agent , legionella , legionnaires' disease , chemistry , antibiotics , biology , bacteria , genetics

The intracellular activity of ABT-773 against Legionella pneumophila was compared with azithromycin and ciprofloxacin using HL-60 cells. Against L. pneumophila ATCC 33152 and three clinical isolates the MICs (mg/L) were ABT-773 0.015, ciprofloxacin 0.03 and azithromycin 0.03. At 48 h, the mean percentage inhibition was as follows: 28.5 +/- 5.9% and 32.6 +/- 4.6% at 8 x and 16 x MIC of ABT-773; 38.1 +/- 8.6% and 48.2 +/- 7.0% at 8 x and 16 x MIC of ciprofloxacin; and 26.3 +/- 9.9% and 28.5 +/- 9.9% at 8 x and 16 x MIC of azithromycin. In this study, all three agents were highly active, with ABT-773 demonstrating similar activity to azithromycin against L. pneumophila.

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