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STM-001, a retargeted glycopeptide, is active against MDR E. coli expressing ESBLs including carbapenemases. Herein, we assessed its capability to combat E. coli complicated urinary tract infections (cUTI) in mice driven by clinically important serine (CTX-M-15) and metallo-β-lactamases (NDM-1).

journal of antimicrobial chemotherapy

Vancomycin-arginine (STM-001) abrogates ESBL carrier and carbapenem-resistant <i>Escherichia coli</i> burden in a murine complicated urinary tract infection model

Vancomycin-arginine (STM-001) abrogates ESBL carrier and carbapenem-resistant Escherichia coli burden in a murine complicated urinary tract infection model