Selection and characterization of mutational resistance to aztreonam/avibactam in β-lactamase-producing Enterobacterales | Zendy

Shazad Mushtaq | Zendy; Anna Vickers | Zendy; Nicholas Ellaby | Zendy; Neil Woodford | Zendy; David M. Livermore | Zendy

Open Access

Selection and characterization of mutational resistance to aztreonam/avibactam in β-lactamase-producing Enterobacterales

Author(s) -

Shazad Mushtaq,

Anna Vickers,

Nicholas Ellaby,

Neil Woodford,

David M. Livermore

Publication year - 2021

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkab346

Subject(s) - aztreonam , ceftazidime/avibactam , avibactam , microbiology and biotechnology , mutant , biology , carbapenem , beta lactamase inhibitors , drug resistance , ceftazidime , genetics , antibiotic resistance , bacteria , antibiotics , pseudomonas aeruginosa , gene , imipenem

Aztreonam/avibactam is being developed for its broad activity against carbapenemase-producing Enterobacterales, including those with metallo-β-lactamases (MBLs). Its potential to select resistance in target pathogens was explored. Findings are compared with previous data for ceftazidime/avibactam and ceftaroline/avibactam.

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