Bactericidal activities and post-antibiotic effects of ofloxacin and ceftriaxone against drug-resistant Salmonella enterica serovar Typhi | Zendy

John Wain | Zendy; J. A. Simpson | Zendy; Luong Thi Diem Nga | Zendy; To Song Diep | Zendy; Duy Pham Thanh | Zendy; Stephen Baker | Zendy; Nicholas Day | Zendy; Nicholas J. White | Zendy; Christopher M. Parry | Zendy

Open Access

Bactericidal activities and post-antibiotic effects of ofloxacin and ceftriaxone against drug-resistant Salmonella enterica serovar Typhi

Author(s) -

John Wain,

J. A. Simpson,

Luong Thi Diem Nga,

To Song Diep,

Duy Pham Thanh,

Stephen Baker,

Nicholas Day,

Nicholas J. White,

Christopher M. Parry

Publication year - 2021

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkab215

Subject(s) - ofloxacin , ceftriaxone , microbiology and biotechnology , typhoid fever , salmonella typhi , antibiotics , antibacterial agent , medicine , ciprofloxacin , chemistry , biology , escherichia coli , biochemistry , gene

The clinical response to ceftriaxone in patients with typhoid fever is significantly slower than with ofloxacin, despite infection with Salmonella enterica serovar Typhi (S. Typhi) isolates with similar susceptibilities (MIC 0.03-0.12 mg/L). The response to ofloxacin is slower if the isolate has intermediate susceptibility (MIC 0.25-1.0 mg/L).

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