CSF concentration of cefotaxime in adult patients with pneumococcal meningitis: a multicentre retrospective study | Zendy

Paul Le Turnier | Zendy; Najoua El Helali | Zendy; Romain Guilhaumou | Zendy; B. Pilmis | Zendy; Matthieu Revest | Zendy; Lionel Velly | Zendy; AnneGaëlle Leroy | Zendy; Xavier Duval | Zendy; F. Lemaı̂tre | Zendy; Matthieu Grégoire | Zendy; Anne-Gaëlle Leroy | Zendy; Najoua El-Helali | Zendy; Florian Lemaitre | Zendy; Jean–Philippe Talarmin | Zendy; JeanLuc Schmit | Zendy; Youssef Bennis | Zendy; Alexandre Charmillon | Zendy; Julien ScalaBertola | Zendy; Joy Mootien | Zendy; Solen Kernéis | Zendy; Firouzé BaniSadr | Zendy; Yohan N’Guyen | Zendy; Zoubir Djerada | Zendy

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CSF concentration of cefotaxime in adult patients with pneumococcal meningitis: a multicentre retrospective study

Author(s) -

Paul Le Turnier,

Najoua El Helali,

Romain Guilhaumou,

B. Pilmis,

Matthieu Revest,

Lionel Velly,

AnneGaëlle Leroy,

Xavier Duval,

F. Lemaı̂tre,

Matthieu Grégoire,

Anne-Gaëlle Leroy,

Najoua El-Helali,

Florian Lemaitre,

Jean–Philippe Talarmin,

JeanLuc Schmit,

Youssef Bennis,

Alexandre Charmillon,

Julien ScalaBertola,

Joy Mootien,

Solen Kernéis,

Firouzé BaniSadr,

Yohan N’Guyen,

Zoubir Djerada

Publication year - 2021

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkab191

Subject(s) - cefotaxime , streptococcus pneumoniae , medicine , meningitis , tolerability , gastroenterology , pneumococcal infections , antibiotics , surgery , microbiology and biotechnology , adverse effect , biology

Pneumococcal meningitis is a devastating disease that requires adequate meningeal antibiotic penetration to limit the mortality. Despite a large usage in this indication, data about CSF concentration of cefotaxime during pneumococcal meningitis in adults are scarce. Therefore, we aimed to describe the CSF concentration obtained after high-dose cefotaxime administration in adult patients treated for Streptococcus pneumoniae meningitis.

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