Zidovudine enhances activity of carbapenems against NDM-1-producing Enterobacteriaceae | Zendy

Yanmin Hu | Zendy; Anthony Coates | Zendy

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Zidovudine enhances activity of carbapenems against NDM-1-producing Enterobacteriaceae

Author(s) -

Yanmin Hu,

Anthony Coates

Publication year - 2021

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkab184

Subject(s) - zidovudine , enterobacteriaceae , broth microdilution , microbiology and biotechnology , meropenem , antibiotics , biology , minimum inhibitory concentration , virology , human immunodeficiency virus (hiv) , antibiotic resistance , escherichia coli , biochemistry , viral disease , gene

Objectives To investigate the efficacy of zidovudine in combination with carbapenems against NDM-1-producing Enterobacteriaceae. Methods MICs were determined using the broth microdilution method. The combinatory effects of zidovudine and carbapenems were examined using the chequerboard method and time–kill analysis. Results We found that the NDM-1-producing strains were resistant to all carbapenems tested. FIC index from chequerboard assay demonstrated that zidovudine synergized with carbapenems against all the NDM-1 strains. Time–kill analysis demonstrated significant synergistic activity when a low level of zidovudine was combined with meropenem. Conclusions Zidovudine in combination with carbapenems produced synergistic activity against NDM-1 Enterobacteriaceae strains in vitro.

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