Presence of HIV-1 G-to-A mutations linked to APOBEC editing is more prevalent in non-B HIV-1 subtypes and is associated with lower HIV-1 reservoir | Zendy

Basma Abdi | Zendy; Sidonie Lambert-Niclot | Zendy; Marc Wirden | Zendy; Aude Jary | Zendy; Elisa Teyssou | Zendy; Sophie Sayon | Zendy; Romain Palich | Zendy; Roland Tubiana | Zendy; Anne Simon | Zendy; MarcAntoine Valantin | Zendy; Christine Katlama | Zendy; Laurence MorandJoubert | Zendy; Vincent Cálvez | Zendy; AnneGeneviève Marcelin | Zendy; Cathia Soulié | Zendy

Open Access

Presence of HIV-1 G-to-A mutations linked to APOBEC editing is more prevalent in non-B HIV-1 subtypes and is associated with lower HIV-1 reservoir

Author(s) -

Basma Abdi,

Sidonie Lambert-Niclot,

Marc Wirden,

Aude Jary,

Elisa Teyssou,

Sophie Sayon,

Romain Palich,

Roland Tubiana,

Anne Simon,

MarcAntoine Valantin,

Christine Katlama,

Laurence MorandJoubert,

Vincent Cálvez,

AnneGeneviève Marcelin,

Cathia Soulié

Publication year - 2021

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkab123

Subject(s) - apobec , biology , stop codon , mutation , reverse transcriptase , genotype , virology , dna , genetics , viral load , human immunodeficiency virus (hiv) , gene , genome , polymerase chain reaction

APOBEC3 editing activity contributes to sequences variation and viral diversification. We aimed to characterize virological and clinical factors associated with G-to-A mutations and stop codons in the HIV-1 reservoir, markers of APOBEC3 footprints, in order to better understand HIV-1 diversity among virologically suppressed HIV-1-infected patients.

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