A mobile microvolume UV/visible light spectrophotometer for the measurement of levofloxacin in saliva | Zendy

JanWillem C. Alffenaar | Zendy; Erwin M. Jongedijk | Zendy; C. Winkel | Zendy; Margaretha Sariko | Zendy; Scott K. Heysell | Zendy; Stellah Mpagama | Zendy; Daan J. Touw | Zendy

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A mobile microvolume UV/visible light spectrophotometer for the measurement of levofloxacin in saliva

Author(s) -

JanWillem C. Alffenaar,

Erwin M. Jongedijk,

C. Winkel,

Margaretha Sariko,

Scott K. Heysell,

Stellah Mpagama,

Daan J. Touw

Publication year - 2020

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkaa420

Subject(s) - saliva , levofloxacin , visible spectrum , chromatography , chemistry , microbiology and biotechnology , materials science , optoelectronics , biology , antibiotics , biochemistry

Therapeutic drug monitoring (TDM) for personalized dosing of fluoroquinolones has been recommended to optimize efficacy and reduce acquired drug resistance in the treatment of MDR TB. Therefore, the aim of this study was to develop a simple, low-cost, robust assay for TDM using mobile UV/visible light (UV/VIS) spectrophotometry to quantify levofloxacin in human saliva at the point of care for TB endemic settings.

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