Relationship of vancomycin trough levels with acute kidney injury risk: an exposure–toxicity meta-analysis | Zendy

Ioannis Bellos | Zendy; G. Daskalakis | Zendy; Vasilios Pergialiotis | Zendy

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Relationship of vancomycin trough levels with acute kidney injury risk: an exposure–toxicity meta-analysis

Author(s) -

Ioannis Bellos,

G. Daskalakis,

Vasilios Pergialiotis

Publication year - 2020

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkaa184

Subject(s) - nephrotoxicity , medicine , trough concentration , acute kidney injury , vancomycin , trough level , meta analysis , renal function , toxicity , creatinine , gastroenterology , surgery , urology , pharmacokinetics , staphylococcus aureus , transplantation , tacrolimus , biology , bacteria , genetics

Nephrotoxicity represents a major complication of vancomycin administration, leading to high rates of morbidity and treatment failure. The aim of this meta-analysis was to evaluate the association between trough levels and risk of renal impairment, by defining an exposure-toxicity relationship and assessing its accuracy in predicting the development of acute kidney injury (AKI).

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