OUP accepted manuscript | Zendy

Josefine Slater | Zendy; Pelle Hanberg | Zendy; Mathias Fichtner Bendtsen | Zendy; Andrea René Jørgensen | Zendy; Eva Greibe | Zendy; Kjeld Søballé | Zendy; Mats Bue | Zendy; Nis Pedersen | Zendy; Maiken Stilling | Zendy

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OUP accepted manuscript

Author(s) -

Josefine Slater,

Pelle Hanberg,

Mathias Fichtner Bendtsen,

Andrea René Jørgensen,

Eva Greibe,

Kjeld Søballé,

Mats Bue,

Nis Pedersen,

Maiken Stilling

Publication year - 2020

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkaa153

Subject(s) - moxifloxacin , microdialysis , rifampicin , medicine , pharmacokinetics , adipose tissue , cancellous bone , pharmacology , urology , spondylodiscitis , subcutaneous tissue , anesthesia , surgery , antibiotics , chemistry , pathology , tuberculosis , biochemistry , central nervous system

Pyogenic spondylodiscitis remains a therapeutic challenge, as demonstrated by divergent treatment guidelines. The combination of moxifloxacin and rifampicin may be an attractive treatment option for cases caused by staphylococci; however, previous studies have reported a reduction in plasma concentrations of moxifloxacin when coadministered with rifampicin. The magnitude of this reduction in spinal tissues is not known.

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