High prevalence of integrase mutation L74I in West African HIV-1 subtypes prior to integrase inhibitor treatment | Zendy

Kate El Bouzidi | Zendy; Steven A. Kemp | Zendy; Rawlings Datir | Zendy; Fati Murtala-Ibrahim | Zendy; Ahmad Aliyu | Zendy; Vivian Kwaghe | Zendy; Dan Frampton | Zendy; Sunando Roy | Zendy; Judith Breuer | Zendy; Caroline Sabin | Zendy; Obinna Ogbanufe | Zendy; Man Charurat | Zendy; David Bonsall | Zendy; Tanya Golubchik | Zendy; Christophe Fraser | Zendy; Patrick Dakum | Zendy; Nicaise Ndembi | Zendy; Ravindra K. Gupta | Zendy

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High prevalence of integrase mutation L74I in West African HIV-1 subtypes prior to integrase inhibitor treatment

Author(s) -

Kate El Bouzidi,

Steven A. Kemp,

Rawlings Datir,

Fati Murtala-Ibrahim,

Ahmad Aliyu,

Vivian Kwaghe,

Dan Frampton,

Sunando Roy,

Judith Breuer,

Caroline Sabin,

Obinna Ogbanufe,

Man Charurat,

David Bonsall,

Tanya Golubchik,

Christophe Fraser,

Patrick Dakum,

Nicaise Ndembi,

Ravindra K. Gupta

Publication year - 2020

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkaa033

Subject(s) - integrase , integrase inhibitor , virology , drug resistance , population , resistance mutation , mutation , biology , human immunodeficiency virus (hiv) , medicine , viral load , genetics , polymerase chain reaction , gene , antiretroviral therapy , reverse transcriptase , environmental health

HIV-1 integrase inhibitors are recommended as first-line therapy by WHO, though efficacy and resistance data for non-B subtypes are limited. Two recent trials have identified the integrase L74I mutation to be associated with integrase inhibitor treatment failure in HIV-1 non-B subtypes. We sought to define the prevalence of integrase resistance mutations, including L74I, in West Africa.

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