Modulation of oxidative burst of neutrophils by doxycycline in patients with acute myocardial infarction | Zendy

Satoshi Takeshita | Zendy

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Modulation of oxidative burst of neutrophils by doxycycline in patients with acute myocardial infarction

Author(s) -

Satoshi Takeshita

Publication year - 2002

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/49.2.411

Subject(s) - doxycycline , myocardial infarction , medicine , pharmacology , respiratory burst , saline , anesthesia , cardiology , immunology , chemistry , antibiotics , biochemistry

We investigated to what extent doxycycline hydrochloride (DOXY) can modify polymorphonuclear leucocyte (PMN) activity in patients with acute myocardial infarction (AMI). PMN activity was measured in blood samples obtained at 0, 15, 30 and 60 min after DOXY administration. In patients receiving saline, PMN activity did not change over 60 min. In contrast, patients receiving DOXY showed a > or = 10% reduction in PMN activity at 30 and 60 min. These data support the use of DOXY to reduce myocardial cell damage by PMNs in patients with AMI.

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