Localization of [14C]amoxicillin in rat gastric tissue when administered with lansoprazole and clarithromycin | Zendy

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Localization of [14C]amoxicillin in rat gastric tissue when administered with lansoprazole and clarithromycin

Author(s) -

H. Endo

Publication year - 2001

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/48.6.923

Subject(s) - lansoprazole , clarithromycin , amoxicillin , medicine , antibacterial agent , helicobacter pylori , pharmacology , gastroenterology , microbiology and biotechnology , antibiotics , biology

The gastric mucosal distribution of [14C]amoxicillin when administered to rats with or without lansoprazole and clarithromycin was investigated. After oral administration, the amount found in the gastric mucosa was higher than after iv administration. Co-administration of lansoprazole and clarithromycin had no apparent effect on the distribution pattern of [14C]amoxicillin within the deeper stomach layers. About 50-60% of the radioactivity in the gastric tissue was present in the mucosal layer, irrespective of the route of administration. Microautoradiograms of the gastric mucosa indicated that [14C]amoxicillin was distributed in both the mucous layer and surface epithelial cells following oral administration. [14C]amoxicillin was secreted mainly by surface epithelial cells after iv administration, although only in small quantities.

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