OXA-35 is an OXA-10-related beta-lactamase from Pseudomonas aeruginosa | Zendy

Dominique Aubert | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

OXA-35 is an OXA-10-related beta-lactamase from Pseudomonas aeruginosa

Author(s) -

Dominique Aubert

Publication year - 2001

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/48.5.717

Subject(s) - aztreonam , imipenem , cefsulodin , ceftazidime , pseudomonas aeruginosa , cefepime , microbiology and biotechnology , beta lactamase , cloxacillin , chemistry , biology , antibiotics , bacteria , biochemistry , penicillin , genetics , escherichia coli , gene

Pseudomonas aeruginosa clinical isolate PA35 is resistant to amino- and ureido-penicillins, has intermediate susceptibility to cefsulodin, cefepime and aztreonam, and is susceptible to imipenem and ceftazidime. Cloning and sequencing revealed a new beta-lactamase variant, OXA-35, sharing 96% amino acid identity with OXA-10. OXA-35 displays a restricted-substrate hydrolysis profile with improved hydrolysis of amoxicillin and cloxacillin compared with OXA-10. OXA-35 differs from derivatives OXA-19 and OXA-28 by one amino acid substitution and may be a progenitor of these OXA-13-like extended-spectrum beta-lactamases.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research