Evaluation of daptomycin susceptibility testing by Etest and the effect of different batches of media | Zendy

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Evaluation of daptomycin susceptibility testing by Etest and the effect of different batches of media

Author(s) -

Peter Fuchs

Publication year - 2001

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/48.4.557

Subject(s) - etest , daptomycin , broth microdilution , agar , microbiology and biotechnology , minimum inhibitory concentration , chemistry , biology , bacteria , antibiotics , vancomycin , staphylococcus aureus , genetics

One hundred and ninety-five Gram-positive bacteria representing 17 species were tested for susceptibility to daptomycin by broth microdilution and Etest methods. The geometric mean daptomycin MIC was 0.46 mg/L by broth microdilution tests and 0.73 mg/L by Etest. The concentration of calcium in 12 different batches of agar varied from 4 to 36 mg/L. Daptomycin Etest MICs varied inversely with the calcium concentration. Etest daptomycin MICs for quality control strains were within proposed quality control range on media with >20 mg/L of calcium. Monitoring the calcium levels of agar media by testing appropriate quality control strains is important for daptomycin Etests.

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